Potassium tert-butoxide → HCID 178441781、化合物

HRID 2173628ノート

反応式

HRID 2173628 の反応式
[C:1]([C:5]1[N:6]=[C:7]([N:14]2[CH2:17][C:16]([CH2:20][OH:21])([CH2:18]Cl)[CH2:15]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].CC(C)([O-])C.[K+]>C1COCC1>[C:1]([C:5]1[N:6]=[C:7]([N:14]2[CH2:17][C:16]3([CH2:20][O:21][CH2:18]3)[CH2:15]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 23665647Potassium tert-butoxideHCID 178441793HCID 178441793、化合物

生成物 1

HCID 178441781HCID 178441781、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of (1-(5-tert-butyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-3-(chloromethyl)azetidin-3-yl)methanol (284 mg, 915 μmol) (example 179, step 2) and potassium tert-butoxide (205 mg, 1.83 mmol) in THF (3 mL) at 0° C. was stirred to room temperature and stirred for 20 h. The mixture was filtered, concentrated in vacuo and used without further purification in the consecutive step.

後処理

  1. stirringstirred for 20 h
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated in vacuo
  4. customused without further purification in the consecutive step

出典と根拠

ORDレコード
ord-d5de93f52aa5419b88f28cd839f3dffe
出典データセット
uspto-grants-2015_06
特許番号
US09056866B2

反応ノート

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