Hydrochloric Acid → 4-methoxyacetoxy-1-phenyl-1,8-naphthyridin-2(1H)-one

HRID 217368

反応式

HRID 217368 の反応式
[OH:1][C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:4](=[O:18])[CH:3]=1.[H-].[Na+].[H][H].[CH3:23][O:24][CH2:25][C:26](Cl)=[O:27].Cl>CN(C=O)C.O>[CH3:23][O:24][CH2:25][C:26]([O:1][C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:4](=[O:18])[CH:3]=1)=[O:27]

参加物

8

反応物 5

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 96623Methoxyacetyl chlorideHCID 546864734-Hydroxy-1-phenyl-1,8-naphthyridin-2(1H)-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 689480664-methoxyacetoxy-1-phenyl-1,8-naphthyridin-2(1H)-one収率 73%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

In accordance with a process described in JP-61-246183A, 4-hydroxy-1-phenyl-1,8-naphthyridin-2(1H)-one was synthesized. To a suspension of the synthesized compound (893 mg, 3.7 mmol) in DMF (20 mL) was added sodium hydride (purity of about 60%, 192 mg, 4.8 mmol, 1.3 eq.), and the mixture was stirred until no more hydrogen was generated. Then, methoxyacetyl chloride (1.07 g, 9.9 mmol, 2.6 eq.) was added thereto, and the mixture was stirred at a room temperature for 50 minutes. To the mixture was added water. The resulting mixture was acidified with concentrated hydrochloric acid, and then the resulting precipitate was separated by filtration and dried to give 4-methoxyacetoxy-1-phenyl-1,8-naphthyridin-2(1H)-one (847 mg, yield 73%).

後処理

  1. customwas synthesized
  2. customthe resulting precipitate was separated by filtration
  3. customdried

出典と根拠

ORDレコード
ord-8cb787f441ec49de8defc03ca7d03e3b
出典データセット
uspto-grants-2012_06
特許番号
US08193356B2

関連ノート

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