Hydrochloric Acid → 3-Amino-5-trifluoromethylpyrazine-2-carboxylic acid

HRID 2173735ノート

反応式

HRID 2173735 の反応式
C([O:3][C:4]([C:6]1[C:11]([NH2:12])=[N:10][C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][N:7]=1)=[O:5])C.[OH-].[Na+].O.Cl>C(O)C>[NH2:12][C:11]1[C:6]([C:4]([OH:5])=[O:3])=[N:7][CH:8]=[C:9]([C:13]([F:16])([F:15])[F:14])[N:10]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 58442356HCID 58442356、化合物2 回

生成物 1

HCID 688182783-Amino-5-trifluoromethylpyrazine-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirring solution of 3-amino-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester (Intermediate 1) (0.5 g, 2.126 mmol) in dry ethanol (5 ml), 2M NaOH (5.32 ml, 10.63 mmol) was added. The yellow solution was stirred at RT. After 5 minutes, the reaction mixture was poured into water (15 ml) and the pH adjusted to pH 6 by addition of 1M HCl. The yellow precipitate formed was filtered under vacuum and dried to yield the title compound. 1H NMR (400 MHz, DMSO-d6) δ 13.65 (1H, s), 8.3 (1H, s), 7.86 (2H, br s)

後処理

  1. customThe yellow precipitate formed
  2. filtrationwas filtered under vacuum
  3. customdried

出典と根拠

ORDレコード
ord-9dd4a7932a9f4e009c5cd52a8a840dc2
出典データセット
uspto-grants-2015_06
特許番号
US09056867B2

反応ノート

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