Methanol → Methyl 2,4,6-trimethylbenzene-1-sulfonate

HRID 2173894ノート

反応式

HRID 2173894 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[S:10](Cl)(=[O:12])=[O:11].[OH-:14].[Na+].[CH3:16]O>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[S:10]([O:12][CH3:16])(=[O:14])=[O:11]

参加物

4

反応物 3

HCID 887Methanol2 回HCID 130462-Mesitylenesulfonyl chlorideHCID 14798Sodium Hydroxide

生成物 1

HCID 13310198Methyl 2,4,6-trimethylbenzene-1-sulfonate収率 96%

実験手順

to a solution of 2,4,6-trimethylbenzene-1-sulfonyl chloride (30 g, 0.136 mol) dissolved in methanol (350 ml), a solution of NaOH (5.49 g, 0.136 mol, 1 equiv.) dissolved in methanol (60 ml) was added dropwise. White NaCl was precipitated and filtered to remove NaCl, and the filtered solution was evaporated, followed by extraction with water and methylene chloride, and the organic layer was obtained, evaporated the solvent therefrom and then dried in a vacuum, affording a white solid at a yield of 96%.

後処理

  1. additionwas added dropwise
  2. customWhite NaCl was precipitated
  3. filtrationfiltered
  4. customto remove NaCl
  5. customthe filtered solution was evaporated
  6. extractionfollowed by extraction with water and methylene chloride
  7. customthe organic layer was obtained
  8. customevaporated the solvent
  9. customdried in a vacuum
  10. customaffording a white solid at a yield of 96%

出典と根拠

ORDレコード
ord-7c0eebe1760e4946aaf165df84aa45b7
出典データセット
uspto-grants-2015_06
特許番号
US09057929B2

反応ノート

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