Nitric Acid → 3-Bromo-2-nitro-benzo(b)thiophene
反応式
[Br:1][C:2]1[C:3]2[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=2[S:5][CH:6]=1.[N+:11]([O-])([OH:13])=[O:12]>C(O)(=O)C>[Br:1][C:2]1[C:3]2[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=2[S:5][C:6]=1[N+:11]([O-:13])=[O:12]参加物
4
実験手順
Into a solution of 3-bromobenzo[b]thiophene (40 g, 190 mmol) in glacial acetic acid (140 ml) was added a solution of nitric acid (74 ml, 1760 mmol) in glacial acetic acid (40 mL) over a period of 45 min. The reaction mixture was stirred at room temperature for 5 hours before quenching with water. The precipitate was isolated by filtration, washed with water and recrystallized from ethyl acetate/hexane (1/1, v/v) to yield 3-bromo-2-nitrobenzo[b]thiophene (35 g, 72%) as yellow crystals.
後処理
- custombefore quenching with water
- customThe precipitate was isolated by filtration
- washwashed with water
- customrecrystallized from ethyl acetate/hexane (1/1
出典と根拠
- ORDレコード
- ord-ac3ad3688ca549dca5a572b7ccefd7bf
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09059412B2
反応ノート
読み込み中…