Water → 3-Bromo-5-(4-methylsulfonylphenyl)pyrazin-2-amine

HRID 2174654ノート

反応式

HRID 2174654 の反応式
C1C(=O)N([Br:8])C(=O)C1.[CH3:9][S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:20]=[CH:21][C:22]([NH2:25])=[N:23][CH:24]=2)=[CH:15][CH:14]=1)(=[O:12])=[O:11].O>CN(C=O)C>[Br:8][C:21]1[C:22]([NH2:25])=[N:23][CH:24]=[C:19]([C:16]2[CH:15]=[CH:14][C:13]([S:10]([CH3:9])(=[O:11])=[O:12])=[CH:18][CH:17]=2)[N:20]=1

参加物

5

反応物 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 580843845-[4-(Methylsulfonyl)phenyl]-2-pyrazinamine

生成物 1

HCID 580843703-Bromo-5-(4-methylsulfonylphenyl)pyrazin-2-amine収率 84%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

NBS (1.807 g, 10.15 mmol) was added to a stirred solution of 5-(4-methylsulfonylphenyl)pyrazin-2-amine (2.53 g, 10.15 mmol) in DMF (40 mL) and the reaction stirred at ambient temperature for 15 hours. The reaction mixture was added slowly to rapidly stirring water and the resultant precipitate was isolated by filtration and dried in vacuo to give the sub-title compound as a beige solid that was used without further purification (2.8 g, 84% Yield).

出典と根拠

ORDレコード
ord-a0da0d13b1674a2f8852c66c22ec0d2c
出典データセット
uspto-grants-2015_06
特許番号
US09062008B2

反応ノート

読み込み中…