Trifluoroacetic acid → HCID 67086667、化合物

HRID 2174972ノート

反応式

HRID 2174972 の反応式
C(OC([N:8]1[CH2:15][CH2:14][CH:13]2[CH:10]([N:11]([C:16]([C:18]3[C:19]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:20][CH:21]=[CH:22][CH:23]=3)=[O:17])[CH2:12]2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>O1CCOCC1>[C:19]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:16]([N:11]1[CH:10]2[CH:13]([CH2:14][CH2:15][NH:8][CH2:9]2)[CH2:12]1)=[O:17]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67086573HCID 67086573、化合物

生成物 1

HCID 67086667HCID 67086667、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 8-(biphenyl-2-carbonyl)-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester in dioxane (8.0 mL) was added trifluoro acetic acid (3 mL), the reaction mixture was stirred for 16 h at room temperature. The solvent and the excess of trifluoro acetic acid were removed under reduced pressure. The resulting trifluoro acetic acid salt of the title compound (388.0 mg was used crude without further purification. MS (ESI) mass calcd. for C19H20N2O, 292.37; m/z found, 293.2 [M+H]+.

後処理

  1. customThe solvent and the excess of trifluoro acetic acid were removed under reduced pressure
  2. customwithout further purification

出典と根拠

ORDレコード
ord-3d9f1bf10e9b4ec69639be730a949fe8
出典データセット
uspto-grants-2015_06
特許番号
US09062044B2

反応ノート

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