Trifluoroacetic acid → 8-(2,4-Dimethyl-benzenesulfonyl)-3,8-diaza-bicyclo[4.2.0]octane

HRID 2174974ノート

反応式

HRID 2174974 の反応式
C(OC([N:8]1[CH2:15][CH2:14][CH:13]2[CH:10]([N:11]([S:16]([C:19]3[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:20]=3[CH3:26])(=[O:18])=[O:17])[CH2:12]2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>O1CCOCC1>[CH3:26][C:20]1[CH:21]=[C:22]([CH3:25])[CH:23]=[CH:24][C:19]=1[S:16]([N:11]1[CH:10]2[CH:13]([CH2:14][CH2:15][NH:8][CH2:9]2)[CH2:12]1)(=[O:18])=[O:17]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 670865848-(2,4-Dimethyl-benzenesulfonyl)-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester

生成物 1

HCID 670869158-(2,4-Dimethyl-benzenesulfonyl)-3,8-diaza-bicyclo[4.2.0]octane

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 8-(2,4-dimethyl-benzenesulfonyl)-3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester in dioxane (8 mL) was added trifluoro acetic acid (3 mL), the reaction mixture was stirred for 16 h at room temperature. The solvent and the excess of trifluoro acetic acid were removed under reduced pressure. The resulting trifluoro acetic acid salt of the title compound was used crude without further purification (150.0 mg, 49%). MS (ESI) mass calcd. for C14H20N2O4S, 280.39; m/z found, 281.2 [M+H]+.

後処理

  1. customThe solvent and the excess of trifluoro acetic acid were removed under reduced pressure
  2. customwithout further purification (150.0 mg, 49%)

出典と根拠

ORDレコード
ord-135325c18fa741f38a73749bec2aad92
出典データセット
uspto-grants-2015_06
特許番号
US09062044B2

反応ノート

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