Benzyl-(6-fluoroindan-1-yl)-amine → 6-Fluoro-2,3-dihydro-1H-inden-1-amine
反応式
C([NH:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([F:18])[CH:16]=2)[CH2:11][CH2:10]1)C1C=CC=CC=1>[Pd].C(O)C>[F:18][C:15]1[CH:16]=[C:17]2[C:12]([CH2:11][CH2:10][CH:9]2[NH2:8])=[CH:13][CH:14]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a high-pressure flask, add 10% palladium on carbon (1.44 g) in ethanol (100 mL). Add a solution of benzyl-(6-fluoroindan-1-yl)-amine (14.44 g, 59.84 mmol) in ethanol (200 mL). Purge the chamber with nitrogen three times, and then with hydrogen three times. Stir vigorously under hydrogen (60 psi) at 50° C. for two hours. Filter the mixture through Celite® 521 and wash the solids with methanol. Concentrate the filtrate in vacuo to give the title compound as a light brown liquid (9.14 g, 100%). MS (ES) m/z=152 [M+1].
後処理
- customPurge the chamber with nitrogen three times
- filtrationFilter the mixture through Celite® 521
- washwash the solids with methanol
- concentrationConcentrate the filtrate in vacuo
出典と根拠
- ORDレコード
- ord-7651103b0a204b1ab55f99235215a63e
- 出典データセット
- uspto-grants-2015_06
- 特許番号
- US09062050B2
反応ノート
読み込み中…