Sodium Bicarbonate → (4,6-Dimethyl-1,2-benzisothiazol-3-yl)-methanol

反応式

C[O:2][C:3]([C:5]1[C:9]2[C:10]([CH3:15])=[CH:11][C:12]([CH3:14])=[CH:13][C:8]=2[S:7][N:6]=1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].C([O-])(O)=O.[Na+]>C1COCC1>[CH3:15][C:10]1[C:9]2[C:5]([CH2:3][OH:2])=[N:6][S:7][C:8]=2[CH:13]=[C:12]([CH3:14])[CH:11]=1

参加物

実験手順

To a solution of 4,6-dimethyl-benzo[d]isothiazole-3-carboxylic acid methyl ester (100 mg, 0.45 mmol) in THF (10 mL) was added lithium aluminum hydride (LiAlH4) (34 mg, 0.9 mmol) at 0° C. under nitrogen atmosphere. The solution was stirred at the same temperature for 1 hour. Sat. NaHCO3 was added and the solution was extracted with EtOAc. The combined organic layer was dried with MgSO4 and filtered. The filtrate was concentrated and the residue was used in the next step of the synthesis without further purification.