HCID 58497414、化合物 → HCID 58497453、化合物
反応式
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:9][NH:10][C:11]1[C:16]([N+:17]([O-])=O)=[CH:15][CH:14]=[CH:13][N:12]=1)[CH2:6][CH2:7][CH3:8])[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:9][NH:10][C:11]1[C:16]([NH2:17])=[CH:15][CH:14]=[CH:13][N:12]=1)[CH2:6][CH2:7][CH3:8])[CH3:2]参加物
4
実験手順
To a solution of 2-[(3-nitro-pyridin-2-ylamino)-methyl]-pentanoic acid ethyl ester (90 mg, 0.32 mmol) in EtOH (5 mL) was added Pd/C (20 mg). The reaction mixture was de-gassed using house vacuum and saturated with H2. The reaction mixture was stirred at room temperature for 18 hours. The mixture was filtered through a pad of celite and the filtrate was concentrated to afford 70 mg (87%) of the desired product which was used for the next reaction without further purification.