Ethyl bromoacetate → Ethyl [(2,3-dimethylphenyl)oxy]acetate

HRID 2175226ノート

反応式

HRID 2175226 の反応式
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].Br[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 106872,3-DimethylphenolHCID 10796Cesium carbonate

生成物 1

HCID 17065225Ethyl [(2,3-dimethylphenyl)oxy]acetate収率 100%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

A mixture of 2,3-dimethylphenol (1.0 g, 8.19 mmol), ethyl bromoacetate (1.0 mL, 9.0 mmol) and cesium carbonate (2.67 g, 8.19 mmol) in DMF (10 mL) was stirred at 80° C. for 16 h. After this time, the reaction mixture was partitioned between EtOAc and water. The organic layer was washed with water and brine, dried and concentrated in vacuo to afford the title compound (1.7 g, 100% yield). LCMS, [M+Na]+=231.0.

後処理

  1. customAfter this time, the reaction mixture was partitioned between EtOAc and water
  2. washThe organic layer was washed with water and brine
  3. customdried
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1c90c4a7e41446c1a2644357b5cbedb8
出典データセット
uspto-grants-2015_06
特許番号
US09062028B2

反応ノート

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