tert-Butyl 3-(bromomethyl)phenylcarbamate → 1-(5-(1-(1-(3-Aminophenyl)ethyl)-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-4-(2,3-dimethylphenoxy)butan-1-one

HRID 2175260

反応式

HRID 2175260 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:35]=[CH:36][CH:37]=1)[CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:12]=2[CH2:13][CH2:14][CH2:15][N:16]3[C:21](=[O:34])[CH2:22][CH2:23][CH2:24][O:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:27]=2[CH3:33])[CH:8]=[N:7]1.Br[CH2:39]C1C=C(NC(=O)OC(C)(C)C)C=CC=1.BrC(C1C=C(NC(=O)OC(C)(C)C)C=CC=1)C>>[NH2:1][C:2]1[CH:3]=[C:4]([CH:5]([N:6]2[CH:10]=[C:9]([C:11]3[CH:20]=[CH:19][CH:18]=[C:17]4[C:12]=3[CH2:13][CH2:14][CH2:15][N:16]4[C:21](=[O:34])[CH2:22][CH2:23][CH2:24][O:25][C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:27]=3[CH3:33])[CH:8]=[N:7]2)[CH3:39])[CH:35]=[CH:36][CH:37]=1

参加物

4

反応物 3

HCID 14523558tert-Butyl 3-(bromomethyl)phenylcarbamateHCID 867125851-(5-(1-(3-Aminobenzyl)-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-4-(2,3-dimethylphenoxy)butan-1-oneHCID 86712586tert-Butyl 3-(1-bromoethyl)phenylcarbamate

生成物 1

HCID 867125871-(5-(1-(1-(3-Aminophenyl)ethyl)-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-4-(2,3-dimethylphenoxy)butan-1-one

実験手順

The title compound was prepared using a procedure analogous to 1-(5-(1-(3-aminobenzyl)-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-4-(2,3-dimethylphenoxy)butan-1-one except that tert-butyl 3-(bromomethyl)phenylcarbamate was replaced with tert-butyl 3-(1-bromoethyl)phenylcarbamate. LCMS, [M+H]+=509.5.

出典と根拠

ORDレコード
ord-6de6a5d602fa405388305c873c898a3a
出典データセット
uspto-grants-2015_06
特許番号
US09062028B2

関連ノート

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