Sodium Cyanide → 3-Cyanopropyltrivinylsilane

HRID 217568

反応式

HRID 217568 の反応式
Cl[CH2:2][CH2:3][CH2:4][Si:5]([CH:10]=[CH2:11])([CH:8]=[CH2:9])[CH:6]=[CH2:7].[C-:12]#[N:13].[Na+]>CN(C)C=O>[C:12]([CH2:2][CH2:3][CH2:4][Si:5]([CH:10]=[CH2:11])([CH:8]=[CH2:9])[CH:6]=[CH2:7])#[N:13]

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 23630656Trivinyl(3-chloropropyl)silane

生成物 1

HCID 579456053-Cyanopropyltrivinylsilane収率 86.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

Compound 3-chloropropyltrivinylsilane (1000 mg, 5.35 mmol) and sodium cyanide (525 mg, 10.70 mmol) were dissolved in 18 ml of dimethylformamide, and the mixture was heated at 70° C. for 4 hours. After the reaction, the organic layer was extracted after addition of distilled water and ether, and then purified by column chromatography (n-Hex:EA=10:1, Rf=0.42), to give 818 mg (86% yield) of pure 3-cyanopropyltrivinylsilane.

後処理

  1. customAfter the reaction
  2. extractionthe organic layer was extracted
  3. additionafter addition of distilled water and ether
  4. custompurified by column chromatography (n-Hex:EA=10:1, Rf=0.42)

出典と根拠

ORDレコード
ord-6de4cb8820464af5bd48ac5f26ac22a1
出典データセット
uspto-grants-2012_06
特許番号
US08197903B2

関連ノート

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