Ethanol → 6-methyl-3-(2H-1,2,3-triazol-2-yl)picolinic acid

HRID 2175935ノート

反応式

HRID 2175935 の反応式
[CH3:1][C:2]1[N:7]=C(C#N)[C:5]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1.[OH-:15].[Na+].[CH3:17][CH2:18][OH:19]>>[CH3:1][C:2]1[N:7]=[C:17]([C:18]([OH:15])=[O:19])[C:5]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 68281582HCID 68281582、化合物

生成物 1

HCID 593637336-methyl-3-(2H-1,2,3-triazol-2-yl)picolinic acid

反応条件

温度
100 °C

実験手順

To a solution of the title compound of Step A (730 mg, 4 mmol) in EtOH (10 mL) was added 4 N NaOH (1 mL, 4 mmol). The mixture was heated at 100° C. for 24 h. The reaction mixture was concentrated in vacuo to a white solid which was used without further purification in subsequent steps.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo to a white solid which
  2. customwas used without further purification in subsequent steps

出典と根拠

ORDレコード
ord-eb837fd85db84ac6b61acf6793cc84d7
出典データセット
uspto-grants-2015_06
特許番号
US09062078B2

反応ノート

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