Benzyl 2,6-difluoro-3-(propane-1-sulfonamido)benzoate → 2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid

HRID 217605ノート

反応式

HRID 217605 の反応式
C([O:8][C:9](=[O:25])[C:10]1[C:15]([F:16])=[CH:14][CH:13]=[C:12]([NH:17][S:18]([CH2:21][CH2:22][CH3:23])(=[O:20])=[O:19])[C:11]=1[F:24])C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[F:24][C:11]1[C:12]([NH:17][S:18]([CH2:21][CH2:22][CH3:23])(=[O:19])=[O:20])=[CH:13][CH:14]=[C:15]([F:16])[C:10]=1[C:9]([OH:25])=[O:8]

参加物

4

反応物 1

HCID 53396460Benzyl 2,6-difluoro-3-(propane-1-sulfonamido)benzoate

生成物 1

HCID 461929232,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

To 2,6-difluoro-3-(propane-1-sulfonylamino)-benzoic acid benzyl ester (52, 2.0 g, mmol) in methanol (30 mL) was added 20% palladium hydroxide on carbon (100 mg). The reaction was stirred under hydrogen at 1 atm for 15 minutes. The reaction was filtered and the filtrate concentrated under vacuum to provide the desired compound.

後処理

  1. filtrationThe reaction was filtered
  2. concentrationthe filtrate concentrated under vacuum

出典と根拠

ORDレコード
ord-2ed296e67d244e4a9be43405a6a05336
出典データセット
uspto-grants-2012_06
特許番号
US08198273B2

反応ノート

読み込み中…