Sodium borohydride → HCID 85877287、化合物

HRID 2176244ノート

反応式

HRID 2176244 の反応式
[C:1]([C:4]1([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:9][O:8][CH2:7][O:6][CH2:5]1)(=[O:3])[CH3:2].[BH4-].[Na+]>C(O)C>[OH:3][CH:1]([C:4]1([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:9][O:8][CH2:7][O:6][CH2:5]1)[CH3:2]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 86706083HCID 86706083、化合物

生成物 1

HCID 85877287HCID 85877287、化合物収率 84.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 5-acetyl-1,3-dioxane-5-carboxylate (2) (22.3 g, 0.11 mol) was dissolved in ethanol (100 mL) and sodium borohydride (2.08 g, 0.055 mol) was added at 0° C. in portions. The mixture was stirred at the same temperature for 1 h. The excess of sodium borohydride was destroyed with acetone and the solution was extracted with ethyl acetate (3×600 mL). The combined organic extracts were concentrated in vacuo to give the title compound (18.9 g, 84%) as colorless oil.

後処理

  1. customThe excess of sodium borohydride was destroyed with acetone
  2. extractionthe solution was extracted with ethyl acetate (3×600 mL)
  3. concentrationThe combined organic extracts were concentrated in vacuo

出典と根拠

ORDレコード
ord-02d4ad1173de45eb84d325529e9fa9e2
出典データセット
uspto-grants-2015_06
特許番号
US09062092B2

反応ノート

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