Lithium hydroxide, monohydrate → 5,5-Dimethyl-2-vinyl-[1,4]dioxane-2-carboxylic acid

HRID 2176321ノート

反応式

HRID 2176321 の反応式
C([O:8][C:9]([C:11]1([CH:19]=[CH2:20])[CH2:16][O:15][C:14]([CH3:18])([CH3:17])[CH2:13][O:12]1)=[O:10])C1C=CC=CC=1.O.[OH-].[Li+]>O1CCCC1.O>[CH3:17][C:14]1([CH3:18])[CH2:13][O:12][C:11]([CH:19]=[CH2:20])([C:9]([OH:10])=[O:8])[CH2:16][O:15]1

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 867061685,5-Dimethyl-2-vinyl-[1,4]dioxane-2-carboxylic acid benzyl ester

生成物 1

HCID 867061705,5-Dimethyl-2-vinyl-[1,4]dioxane-2-carboxylic acid収率 54.2%

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

To a stirred solution of 5,5-dimethyl-2-vinyl-[1,4]dioxane-2-carboxylic acid benzyl ester (189 mg, 0.684 mmol) in tetrahydrofuran (7 mL) at 0° C. was added a solution of lithium hydroxide hydrate (34 mg, 0.821 mmol) in water (1.6 mL). The reaction mixture was stirred at 0° C. for 30 min and allowed to warm to ambient temperature and stirred for 19 h. The mixture was diluted with water and washed with ethyl acetate (2×). The aqueous layer was acidified to pH 5 with hydrochloric acid (2 M) and extracted with ethyl acetate (2×). The organic extracts were dried over anhydrous magnesium sulfate, filtered and evaporated to give the title compound (69 mg, 54%) as a colorless oil. 1H NMR (300 MHz, CDCl3): δ 1.19 (s, 3H), 1.32 (s, 3H), 3.58 (d, J=11.8 Hz, 1H), 3.72 (d, J=11.8 Hz, 1H), 3.75 (d, J=12.3 Hz, 1H), 4.21 (d, J=12.3 Hz, 1H), 5.39 (dd, J=10.7, 0.9 Hz, 1H), 5.60 (dd, J=17.4, 0.9 Hz, 1H), 5.84 (dd, J=17.4, 10.7 Hz, 1H). LCMS (m/z) 185.2 [M−H], Tr=1.32 min.

後処理

  1. temperatureto warm to ambient temperature
  2. stirringstirred for 19 h
  3. washwashed with ethyl acetate (2×)
  4. extractionextracted with ethyl acetate (2×)
  5. dry with materialThe organic extracts were dried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-f6c10009526e4b5cb70787e527e5b23b
出典データセット
uspto-grants-2015_06
特許番号
US09062092B2

反応ノート

読み込み中…