戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 2176779作成日：2026年10月26日

3-(Methylcarbamoyl)propanoic acid → (3aR,4S,7aR)-methyl 4-(4-(methylamino)-4-oxobutanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate

https://huagongshe.com/reaction/2176779

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Methylcarbamoyl)propanoic acidHCID 292050—
反応物(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl esterHCID 68276168—
生成物(3aR,4S,7aR)-methyl 4-(4-(methylamino)-4-oxobutanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylateHCID 86702180—

反応手順

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and N-methylsuccinamic acid to yield (3aR,4S,7aR)-methyl 4-(4-(methylamino)-4-oxobutanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate. MS [M+H]=427; RT=1.06 min; UPLC Method I

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09067881B2
出典データセットuspto-grants-2015_06
ORD IDord-dcf85e8d928040f58183a4343805165e
出典メモuspto-grants-2015_06