5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile → 5-(4-Chlorophenyl)-2-hydroxypyridine

HRID 2177

反応式

HRID 2177 の反応式
C([C:3]1[C:4](=[O:16])[NH:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH:8]=1)#N>OP(O)(O)=O>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([C:7]2[CH:8]=[CH:3][C:4](=[O:16])[NH:5][CH:6]=2)=[CH:14][CH:13]=1

参加物

3

反応物 1

HCID 27639105-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

生成物 1

HCID 102623725-(4-Chlorophenyl)-2-hydroxypyridine収率 75.6%

試薬・触媒・溶媒 1

HCID 1004Phosphoric Acid溶媒

実験手順

A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-354b2e3cf6af4b84a2f7d3ebed5eb64d
出典データセット
uspto-grants-1998_03
特許番号
US05728715

関連ノート

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