5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile → 5-(4-Chlorophenyl)-2-hydroxypyridine
反応式
C([C:3]1[C:4](=[O:16])[NH:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH:8]=1)#N>OP(O)(O)=O>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([C:7]2[CH:8]=[CH:3][C:4](=[O:16])[NH:5][CH:6]=2)=[CH:14][CH:13]=1参加物
3
実験手順
A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.
後処理
- temperaturewas heated
- temperatureat reflux for 16 hours
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-354b2e3cf6af4b84a2f7d3ebed5eb64d
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05728715
反応ノート
読み込み中…