4-(Trifluoromethyl)mandelic acid → 1-[4-(trifluoromethyl)phenyl]ethane-1,2-diol

HRID 2177056

反応式

HRID 2177056 の反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8](O)=[O:9])=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:1][C:2]([F:14])([F:15])[C:3]1[CH:4]=[CH:5][C:6]([CH:7]([OH:11])[CH2:8][OH:9])=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 1645934-(Trifluoromethyl)mandelic acidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 114811481-[4-(trifluoromethyl)phenyl]ethane-1,2-diol収率 85.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 4-trifluoromethylmandelic acid (1.0 g, 4.54 mmol) in tetrahydrofuran was added lithium aluminum hydride (0.36 g, 9.54 mmol). The reaction mixture was refluxed for 1.5 hours. The reaction mixture was quenched with sat. ammonium chloride solution, filtered, concentrated to yield 0.8 g of 1-(4-trifluoromethylphenyl)ethane-1,2-diol.

後処理

  1. temperatureThe reaction mixture was refluxed for 1.5 hours
  2. customThe reaction mixture was quenched with sat. ammonium chloride solution
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-0384710f2a0a4d3c94d8d994b4e1caec
出典データセット
uspto-grants-2015_06
特許番号
US09067897B2

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