関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-(2-Bromo-4-chlorophenyl)ethanone | HCID 4712644 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-(4-Chlorophenyl)-2-oxoethyl acetate | HCID 587254 | 90.1% |
反応手順
To a cooled (4° C.) and stirred solution of 2-bromo-4-chloroacetophenone (5.0 g, 21.41 mmol) and glacial acetic acid (2.8 mL, 49.25 mmol) in acetonitrile was added triethylamine (6.1 mL, 44.97 mmol). The reaction mixture was warmed to room temperature, than refluxed for 3 hours. The reaction mixture was extracted with ether, acetate, washed with 1N hydrochloric acid, brine, dried, and concentrated to yield 4.1 g of acetic acid 2-(4-chlorophenyl)-2-oxo-ethyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09067897B2 |
|---|
| 出典データセット | uspto-grants-2015_06 |
|---|
| ORD ID | ord-254c1c65fedf4bc7b980642b38967d0e |
|---|
| 出典メモ | uspto-grants-2015_06 |
|---|
