反应详情

温度

4 °C

To a cooled (4° C.) and stirred solution of 2-bromo-4-chloroacetophenone (5.0 g, 21.41 mmol) and glacial acetic acid (2.8 mL, 49.25 mmol) in acetonitrile was added triethylamine (6.1 mL, 44.97 mmol). The reaction mixture was warmed to room temperature, than refluxed for 3 hours. The reaction mixture was extracted with ether, acetate, washed with 1N hydrochloric acid, brine, dried, and concentrated to yield 4.1 g of acetic acid 2-(4-chlorophenyl)-2-oxo-ethyl ester.

1. temperatureThe reaction mixture was warmed to room temperature
2. temperaturethan refluxed for 3 hours
3. extractionThe reaction mixture was extracted with ether, acetate
4. washwashed with 1N hydrochloric acid, brine
5. customdried
6. concentrationconcentrated