2-Methoxy-1-phenylethanone → 2-Methoxy-1-phenylethan-1-ol

HRID 2177059ノート

反応式

HRID 2177059 の反応式
[CH3:1][O:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>C(O)C>[CH3:1][O:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5]

参加物

4

反応物 2

HCID 776982-Methoxy-1-phenylethanoneHCID 4311764Sodium borohydride

生成物 1

HCID 5722942-Methoxy-1-phenylethan-1-ol収率 78.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of 2-methoxy-1-phenylethanone (1.0 g, 6.66 mmol) in ethanol was added sodium borohydride (0.28 g, 7.32 mmol). The reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was quenched with sat. ammonium chloride solution, concentrated. Extracted with ethyl acetate, washed with brine, dried, and concentrated to yield 0.8 g of 2-methoxy-1-phenylethanol.

後処理

  1. customThe reaction mixture was quenched with sat. ammonium chloride solution
  2. concentrationconcentrated
  3. extractionExtracted with ethyl acetate
  4. washwashed with brine
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-319bf6ac8f264037b5baa63ae110b16d
出典データセット
uspto-grants-2015_06
特許番号
US09067897B2

反応ノート

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