Trifluoroacetic acid → N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-3-fluoropropane-1-sulfonamide trifluoroacetate

HRID 2177076ノート

反応式

HRID 2177076 の反応式
C(OC(=O)[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH2:18][NH:19][S:20]([CH2:23][CH2:24][CH2:25][F:26])(=[O:22])=[O:21])=[CH:13][CH:14]=2)[CH:9]1[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>ClCCl>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[NH2:7][CH:8]1[CH:9]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:10]2[CH:11]=[C:12]([CH2:18][NH:19][S:20]([CH2:23][CH2:24][CH2:25][F:26])(=[O:22])=[O:21])[CH:13]=[CH:14][C:15]=2[CH2:16][CH2:17]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59547781HCID 59547781、化合物

生成物 1

HCID 68507572N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-3-fluoropropane-1-sulfonamide trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Tert-butyl[1-benzyl-7-({[(3-fluoropropyl)sulfonyl]amino}methyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (9.3 mg, 0.019 mmol) was dissolved in dichloromethane (10 mL) and trifluoroacetic acid (excess) was added. The reaction mixture was stirred at room temperature for 4 h. The solvent was evaporated in vacuo and the crude product was purified by flash chromatography (silica gel, dichloromethane, methanol).

後処理

  1. customThe solvent was evaporated in vacuo
  2. customthe crude product was purified by flash chromatography (silica gel, dichloromethane, methanol)

出典と根拠

ORDレコード
ord-1d820a63c5014f2eb2671ae21ed457f9
出典データセット
uspto-grants-2015_06
特許番号
US09067871B2

反応ノート

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