化工社化工社 化学情報印刷レポート · 研究参考用
Methyl iodide → 1-(3-Hydroxy-5-methoxyphenyl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3',5'-Dihydroxyacetophenone | HCID 103993 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-(3-Hydroxy-5-methoxyphenyl)ethanone | HCID 19350666 | 34.2% |
反応手順
1-(3,5-Dihydroxyphenyl)ethanone (3 g) and methyl iodide (2.80 g) were dissolved in DMF (40 ml), and sodium hydride (568 mg) was added. After stirring at RT for 2 h, the DMF was drawn off. The residue was taken up in EA and washed with water, dried, filtered and concentrated. The residue was purified using silica gel (89 g cartridge, n-heptane/EA 0-50% within 30 min). 1.12 g of the title compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08198272B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-f95df772e1fa45d7b30c9cdf1ff92fb1 |
| 出典メモ | uspto-grants-2012_06 |