HCID 59438495、化合物 → HCID 59438445、化合物

HRID 2177494ノート

反応式

HRID 2177494 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][C:4]([N+:14]([O-])=O)([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH2:3]1>C1COCC1.[Ni]>[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][C:4]([NH2:14])([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH2:3]1

参加物

4

反応物 1

HCID 59438495HCID 59438495、化合物

生成物 1

HCID 59438445HCID 59438445、化合物収率 100.1%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

To a 0° C. cooled solution of 52 mg (0.235 mmol) rac-1-Methyl-3-nitro-1,2,3,4,5,6-hexahydro-[3,4′]bipyridinyl in 2.0 ml THF were added 150 ul of Raney Nickel (50% in water). The mixture was stirred at 0° C. under a hydrogen atmosphere for 7 hours. The catalyst was filtered and the filtrate was concentrated in vacuo to provide 45 mg (88%) of the title compound as a light yellow oil. MS (m/e): 192.4 (M+H).

後処理

  1. filtrationThe catalyst was filtered
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-104134f2fd98461a8c44f87dbba9999f
出典データセット
uspto-grants-2015_06
特許番号
US09067911B2

反応ノート

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