Methanol → Methyl 3-tert-butyl-5-hydroxybenzoate

HRID 217759ノート

反応式

HRID 217759 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([OH:14])[CH:13]=1)[C:8]([OH:10])=[O:9])([CH3:4])([CH3:3])[CH3:2].S(Cl)(Cl)=O.[CH3:19]O>>[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([OH:14])[CH:13]=1)[C:8]([O:10][CH3:19])=[O:9])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 217986673-t-Butyl-5-hydroxybenzoic acid

生成物 1

HCID 53399216Methyl 3-tert-butyl-5-hydroxybenzoate

実験手順

3-tert-Butyl-5-hydroxybenzoic acid (O7.043; 1.93 g) was dissolved in methanol (20 ml), and thionyl chloride (0.937 ml) was slowly added dropwise while stirring. After stirring at 65° C. for 1 h, the mixture was dried, the residue was taken up in DCM, and the solution was washed with saturated sodium hydrogencarbonate solution, dried over MgSO4, filtered and concentrated by rotary evaporation. 2.19 g of the title compound were obtained.

後処理

  1. stirringAfter stirring at 65° C. for 1 h
  2. customthe mixture was dried
  3. washthe solution was washed with saturated sodium hydrogencarbonate solution
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated by rotary evaporation

出典と根拠

ORDレコード
ord-87a3d0e57e1e4a38bee413a0684a8b50
出典データセット
uspto-grants-2012_06
特許番号
US08198272B2

反応ノート

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