Propionic Acid → 2-ethyl-1-phenyl-1H-imidazo[4,5-c]pyridine

HRID 2177625

反応式

HRID 2177625 の反応式
[C:1]1([NH:7][C:8]2[CH:13]=[CH:12][N:11]=[CH:10][C:9]=2[NH2:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15](O)(=O)[CH2:16][CH3:17]>P(Cl)(Cl)(Cl)=O>[CH2:16]([C:17]1[N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]2[CH:13]=[CH:12][N:11]=[CH:10][C:9]=2[N:14]=1)[CH3:15]

参加物

4

反応物 2

HCID 1032Propionic AcidHCID 105836754-N-phenylpyridine-3,4-diamine

生成物 1

HCID 904095952-ethyl-1-phenyl-1H-imidazo[4,5-c]pyridine収率 19.3%

試薬・触媒・溶媒 1

HCID 24813Phosphorus oxychloride溶媒

実験手順

A mixture of N4-phenylpyridine-3,4-diamine (8.0 g, 37.2 mmol), propionic acid (2.7 g, 37.2 mmol) and phosphorous oxychloride (50 mL) was stirred at reflux for 10 h. The reaction was purified by silica gel chromatography using ethyl acetate to afford the product as a solid (1.6 g, 19%).

後処理

  1. temperatureat reflux for 10 h
  2. customThe reaction was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-7cd3cb1fb65b4173a4000af600bf5e42
出典データセット
uspto-grants-2015_06
特許番号
US09066946B2

関連ノート

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