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3-Aminopyridine → 3-Amino-6-bromo-N-pyridin-3-ylpyrazine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminopyridine | HCID 10009 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | 3-Amino-6-bromopyrazine-2-carboxylic acid | HCID 18521600 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Amino-6-bromo-N-pyridin-3-ylpyrazine-2-carboxamide | HCID 10402162 | 79.3% |
反応手順
To a solution of the product of step (iv) (100 g, 0.45 mol) in DMF (350 mL) was added TEA (129 mL, 0.91 mol) and 3-aminopyridine (42.3 g, 0.45 mol). HATU (174 g, 0.45 mol) was added to the solution portionwise. The suspension was filtered, washed with water and dried under a reduced pressure to afford the subtitle compound (v) as a yellow solid (105 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08198285B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-27e1bc192fcf4223a0e32d07d6ecb165 |
| 出典メモ | uspto-grants-2012_06 |