Trifluoromethanesulfonic anhydride → HCID 88853052、化合物

HRID 2178099ノート

反応式

HRID 2178099 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[O:14](S(C(F)(F)F)(=O)=O)[S:15]([C:18]([F:21])([F:20])[F:19])(=O)=[O:16]>C(Cl)Cl>[F:19][C:18]([F:21])([F:20])[S:15]([O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[C:10]([F:11])([F:12])[F:13])(=[O:16])=[O:14]

参加物

4

反応物 2

HCID 67749Trifluoromethanesulfonic anhydrideHCID 70215934-Hydroxy-3-(trifluoromethyl)benzaldehyde

生成物 1

HCID 88853052HCID 88853052、化合物収率 66%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of 4-hydroxy-3-(trifluoromethyl)benzaldehyde (500 mg, 2.7 mmol), TEA (805 mg, 8.0 mmol) in anhydrous DCM (10 mL) was added Tf2O (820 mg, 2.9 mmol) drop wise at 0° C., and stirred at the same temperature for 30 mins. Followed a standard aqueous/EtOAc workup and purified by column chromatography (PE:EtOAc=10:1) to give product (560 mg, 66% yield).

後処理

  1. customFollowed a standard aqueous/EtOAc workup and purified by column chromatography (PE:EtOAc=10:1)

出典と根拠

ORDレコード
ord-4e41a3fb0f844b3c9596ae8a6271c0f5
出典データセット
uspto-grants-2015_06
特許番号
US09067893B2

反応ノート

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