(S)-1-[3-(4-Methoxy-benzyl)-5-(2,2,2-trifluoro-ethoxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol → HCID 178521640、化合物
反応式
COC1C=CC(C[N:8]2[C:12]3[N:13]=[C:14]([O:23][CH2:24][C:25]([F:28])([F:27])[F:26])[N:15]=[C:16]([N:17]4[CH2:21][CH2:20][C@H:19]([OH:22])[CH2:18]4)[C:11]=3[N:10]=[N:9]2)=CC=1>C(O)(C(F)(F)F)=O>[F:27][C:25]([F:26])([F:28])[CH2:24][O:23][C:14]1[N:15]=[C:16]([N:17]2[CH2:21][CH2:20][C@H:19]([OH:22])[CH2:18]2)[C:11]2[N:10]=[N:9][NH:8][C:12]=2[N:13]=1参加物
3
実験手順
(S)-1-[3-(4-Methoxy-benzyl)-5-(2,2,2-trifluoro-ethoxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol (example 109, d) in 4.57 mL TFA was heated to 80° C. over night and evaporated. The residue was treated with 1M NaOH and washed with EtOAc. The combined organic layer was evaporated to yield the crude title compound which was used in the consecutive step without further purification. MS (m/e): 305.2 (MH+).
後処理
- customevaporated