2-Methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-3-nitro-pyridine → 2-Methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-ylamine

HRID 2180000ノート

反応式

HRID 2180000 の反応式
[CH3:1][O:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][C:6]([CH3:12])=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:15][C:14]=2[O:24][CH3:25])[N:4]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[C:8]([NH2:9])=[CH:7][C:6]([CH3:12])=[C:5]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]([F:22])([F:23])[F:21])=[CH:15][C:14]=2[O:24][CH3:25])[N:4]=1

参加物

4

反応物 1

HCID 224900612-Methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-3-nitro-pyridine

生成物 1

HCID 224900462-Methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-ylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Pd/C (10%, 1.6 g) is added to a solution of 2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-3-nitro-pyridine (16.35 g, 45.635 mmol) in MeOH (450 ml) at room temperature. The suspension is stirred under hydrogen at room temperature for 5 hours. The catalyst is removed by filtration and the filtrate is concentrated under reduced pressure to give 2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-ylamine as a gum. Rf (hexane/EtOAc=9:1)=0.18.

後処理

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-3d139b60315249ae9fff8b2a620c3215
出典データセット
uspto-grants-2005_05
特許番号
US06887875B2

反応ノート

読み込み中…