7-Benzyloxy-4-chloro-6-methoxycinnoline hydrochloride → 4-Chloro-7-hydroxy-6-methoxycinnoline

HRID 2180119

反応式

HRID 2180119 の反応式
Cl.C([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([Cl:20])=[CH:15][N:16]=[N:17]2)=[CH:12][C:11]=1[O:21][CH3:22])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[Cl:20][C:14]1[C:13]2[C:18](=[CH:19][C:10]([OH:9])=[C:11]([O:21][CH3:22])[CH:12]=2)[N:17]=[N:16][CH:15]=1

参加物

3

反応物 1

HCID 219910077-Benzyloxy-4-chloro-6-methoxycinnoline hydrochloride

生成物 1

HCID 1357525234-Chloro-7-hydroxy-6-methoxycinnoline収率 94%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 7-benzyloxy-4-chloro-6-methoxycinnoline hydrochloride (3.06 g, 9 mmol), in TFA (30 ml) was heated at reflux for 5 hours. After evaporation of the solvent, the residue was suspended in water and adjusted to pH7 with saturated aqueous sodium hydrogen carbonate solution. The resulting solid was filtered off, washed with water and ether and dried under vacuum to give 4-chloro-7-hydroxy-6-methoxycinnoline as a yellow solid (1.78 g, 94%).

後処理

  1. temperatureat reflux for 5 hours
  2. customAfter evaporation of the solvent
  3. filtrationThe resulting solid was filtered off
  4. washwashed with water and ether
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-0ab58c77ede44c7db135dbd692d651d1
出典データセット
uspto-grants-2005_05
特許番号
US06887874B2

関連ノート

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