Water → 5-Ethoxypyrazine-2-carboxylic acid
反応式
[OH-].[Na+].Cl[C:4]1[N:5]=[CH:6][C:7]([C:10]([O:12]C)=[O:11])=[N:8][CH:9]=1.[C:14](OCC)(=[O:16])[CH3:15].O>C(O)C>[CH2:14]([O:16][C:4]1[N:5]=[CH:6][C:7]([C:10]([OH:12])=[O:11])=[N:8][CH:9]=1)[CH3:15]参加物
6
実験手順
A 5 N sodium hydroxide solution (2 mL) was added to a solution of methyl 5-chloropyrazine-2-carboxylate (150 mg) in ethanol (4 mL), and the mixture was stirred at room temperature for five hours. Ethyl acetate and water were added to the reaction solution, and the aqueous layer was separated. The aqueous layer was made acidic with concentrated hydrochloric acid. Brine and ethyl acetate were added to the mixture, and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate. The organic layer was concentrated to obtain the title compound (135 mg).
後処理
- customthe aqueous layer was separated
- additionBrine and ethyl acetate were added to the mixture
- customthe organic layer was separated
- dry with materialThe organic layer was dried over anhydrous magnesium sulfate
- concentrationThe organic layer was concentrated
出典と根拠
- ORDレコード
- ord-ebc8795a9ed044dfbb706bb91aad0322
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08198269B2
反応ノート
読み込み中…