Water → 1H-Benzimidazole-4-carbohydrazide
反応式
C[O:2][C:3]([C:5]1[C:10]2[N:11]=[CH:12][NH:13][C:9]=2[CH:8]=[CH:7][CH:6]=1)=O.O.[NH2:15][NH2:16].O>CCO>[N:11]1[C:10]2[C:5]([C:3]([NH:15][NH2:16])=[O:2])=[CH:6][CH:7]=[CH:8][C:9]=2[NH:13][CH:12]=1参加物
5
実験手順
Benzimidazole ester 3 (1.65 g, 9.36 mmol), hydrazine monohydrate (10 mL), and water (3 mL) were refluxed in EtOH (60 mL) for 24 hs. Reaction mixture was cooled to room temperature and solid formed was filtered, washed with EtOH and dried to give 1.13 g (68%) of pure 4: 1H NMR (DMSO-d6) δ 12.31 (br.s, 1H), 10.59 (s, 1H), 8.44 (s, 1H), 7.86 (d, 1H, J=6.5 Hz), 7.76 (d, 1H, J=8.0 Hz), 7.34 (t, 1H, J=8.0 Hz), 4.68 (s, 2H).
後処理
- customReaction mixture
- customsolid formed
- filtrationwas filtered
- washwashed with EtOH
- customdried
- customto give 1.13 g (68%) of pure 4
出典と根拠
- ORDレコード
- ord-29a7ecfe00e6434b8806fc474de3f30c
- 出典データセット
- uspto-grants-2005_05
- 特許番号
- US06887996B2
反応ノート
読み込み中…