Iodoethane → HCID 22490903、化合物
反応式
[Br:1][C:2]1[C:3]([OH:14])=[CH:4][C:5]2[C:6]([CH3:13])([CH3:12])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1.I[CH2:16][CH3:17].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5](=[CH:4][C:3]=1[O:14][CH2:16][CH3:17])[C:6]([CH3:12])([CH3:13])[CH2:7][CH2:8][CH2:9]2参加物
5
実験手順
A mixture of 3-bromo-8,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-ol (Compound A-2, 5.77 g, 22.62 mmol); iodoethane (7.2 mL, 90.5 mmol), and potassium carbonate (4.68 g, 34 mmol) in acetone (50 mL) was stirred at 70° C. overnight. The solvent was removed in vacuo. The residue was purified by column chromatography (silica gel, 2.5% ethyl acetate in hexane) to afford the title compound as a pale yellow oil.
後処理
- customThe solvent was removed in vacuo
- customThe residue was purified by column chromatography (silica gel, 2.5% ethyl acetate in hexane)
出典と根拠
- ORDレコード
- ord-a97d516d6c6c4453877cac370b20b4d9
- 出典データセット
- uspto-grants-2005_05
- 特許番号
- US06887896B1
反応ノート
読み込み中…