Ethanethiol → HCID 22490915、化合物
反応式
[H-].[Na+].C(S)C.[Br:6][C:7]1[C:16]2[C:15]([CH3:18])([CH3:17])[CH2:14][CH:13]=[C:12]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:11]=2[CH:10]=[C:9]([C:23](=[O:25])[CH3:24])[C:8]=1[O:26]C>CN(C)C=O>[Br:6][C:7]1[C:16]2[C:15]([CH3:17])([CH3:18])[CH2:14][CH:13]=[C:12]([C:19]([CH3:21])([CH3:20])[CH3:22])[C:11]=2[CH:10]=[C:9]([C:23](=[O:25])[CH3:24])[C:8]=1[OH:26]参加物
5
実験手順
As described in General Procedure L-1, sodium hydride (211 mg, 5.28 mmol) and ethanethiol (0.39 mL, 5.28 mmol) was treated with a solution of 1-(4-bromo-8-tert-butyl-3-methoxy-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-ethanone (Compound A-104, 536 mg, 1.47 mmol) in N,N-dimethylformamide to afford the title compound after purification by flash chromatography (silica gel, 5% ethyl acetate in hexane).