Sodium Hydroxide → HCID 22490777、化合物

HRID 2180634ノート

反応式

HRID 2180634 の反応式
[Br:1][C:2]1[C:11]2[C:10]([CH3:13])([CH3:12])[CH2:9][CH:8]=[C:7]([CH:14]([CH3:16])[CH3:15])[C:6]=2[CH:5]=[C:4](/[C:17](/[CH3:30])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([O:25]CC)=[O:24])[C:3]=1[O:31][CH2:32][CH3:33].[OH-].[Na+]>C(O)C>[Br:1][C:2]1[C:11]2[C:10]([CH3:13])([CH3:12])[CH2:9][CH:8]=[C:7]([CH:14]([CH3:16])[CH3:15])[C:6]=2[CH:5]=[C:4](/[C:17](/[CH3:30])=[C:18](/[F:29])\[CH:19]=[CH:20]\[C:21](\[CH3:28])=[CH:22]\[C:23]([OH:25])=[O:24])[C:3]=1[O:31][CH2:32][CH3:33]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86759717HCID 86759717、化合物2 回

生成物 1

HCID 22490777HCID 22490777、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

As described in General Procedure J-1, ethyl (2E,4E,6E)-7-(4 bromo-3-ethoxy-8-isopropyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-6 fluoro-3-methyl-octa-2,4,6-trienoate (Compound A-158, 860 mg, 1.65 mmol) in ethanol was treated with a solution of 1 N NaOH to produce the title compound after purification by recrystallization from acetonitrile.

出典と根拠

ORDレコード
ord-40277213822e479196520c180b39a62f
出典データセット
uspto-grants-2005_05
特許番号
US06887896B1

反応ノート

読み込み中…