Pyridine → Phenol, 3-chloro-4-methyl-, acetate

HRID 2181015

反応式

HRID 2181015 の反応式
[C:1]([O:4][C:5](=[O:7])[CH3:6])(=O)[CH3:2].N1C=CC=CC=1.[Cl:14][C:15]1C=C(O)[CH:18]=[CH:19][C:20]=1[CH3:21]>CCOCC>[C:5]([O:4][C:1]1[CH:18]=[CH:19][C:20]([CH3:21])=[C:15]([Cl:14])[CH:2]=1)(=[O:7])[CH3:6]

参加物

5

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 148533-Chloro-4-methylphenol

生成物 1

HCID 538898Phenol, 3-chloro-4-methyl-, acetate収率 99.6%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Acetic anhydride (430 mg) and pyridine (416 mg) were added to a solution of 3-chloro-4-methylphenol (500 mg) in ether (5.0 ml), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was washed once with 1N hydrochloric acid and twice with saturated brine, dried over magnesium sulfate, and concentrated to dryness under reduced pressure to give 4-acetoxy-2-chlorotoluene as a pale-yellow oil (645 mg).

後処理

  1. washThe reaction mixture was washed once with 1N hydrochloric acid and twice with saturated brine
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-79eae0ab6e924be499d5289f2e5fa59c
出典データセット
uspto-grants-2005_05
特許番号
US06890934B2

関連ノート

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