Thionyl Chloride → cis-2-Pentenyl 5-aminolevulinate hydrochloride
反応式
S(Cl)([Cl:3])=O.Cl.[NH2:6][CH2:7][C:8](=[O:14])[CH2:9][CH2:10][C:11]([OH:13])=[O:12]>CN(C)C=O>[ClH:3].[NH2:6][CH2:7][C:8](=[O:14])[CH2:9][CH2:10][C:11]([O:13][CH2:7]/[CH:8]=[CH:9]\[CH2:10][CH3:11])=[O:12]参加物
4
実験手順
To 1 ml of thionyl chloride (SOCl2) were added 3 drops of N,N-dimethylformamide (DMF) with stirring. Following the addition of 5-aminolevulinic acid hydrochloride (ALA.HCl, 200 mg, 1.19 mol), the solution was stirred for 12 hours at room temperature. Concentration in a vacuum was conducted before the addition of cis-2-pentenol. Then, the reaction mixture was stirred for 1.5 hours at room temperature, followed by purification by silica gel chromatography to afford cis-2-pentenyl 5-aminolevulinate hydrochloride at a yield of 68%.
後処理
- stirringthe solution was stirred for 12 hours at room temperature
- concentrationConcentration in a vacuum
- additionwas conducted before the addition of cis-2-pentenol
- stirringThen, the reaction mixture was stirred for 1.5 hours at room temperature
- customfollowed by purification by silica gel chromatography
出典と根拠
- ORDレコード
- ord-92f2949129df4026b4bef3e1ee5a7506
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08198325B2
反応ノート
読み込み中…