Silane, ((1-methoxy-2-methyl-1-propenyl)oxy)trimethyl- → HCID 59251058、化合物

HRID 218127

反応式

HRID 218127 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17](O)[CH2:18][CH:19]([CH3:21])[CH3:20])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[CH3:23][O:24][C:25]([O:29][Si](C)(C)C)=[C:26]([CH3:28])[CH3:27]>C(Cl)Cl.Cl[Ti](Cl)(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:26]([CH3:28])([CH3:27])[C:25]([O:24][CH3:23])=[O:29])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 552336Silane, ((1-methoxy-2-methyl-1-propenyl)oxy)trimethyl-HCID 670061961-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-methylbutan-1-ol

生成物 1

HCID 59251058HCID 59251058、化合物

試薬・触媒・溶媒 2

HCID 24193Titanium Tetrachloride触媒HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 1-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-methylbutan-1-ol (0.41 mmol) in 20 mL of CH2Cl2 at 0° C. was added 1M TiCl4 in CH2Cl2 (0.5 mmol) all at once. After 30 min, (1-methoxy-2-methylprop-1-enyloxy)trimethylsilane (0.24 mL, 1.2 mmol) was added and the reaction was warmed to rt and stirred overnight. The reaction was quenched with water and extracted with CH2Cl2. The CH2Cl2 extracts were dried over MgSO4, filtered, and concentrated by rotary evaporator to give methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2,5-trimethylhexanoate. MS found: (M+H)+=383.

後処理

  1. customThe reaction was quenched with water
  2. extractionextracted with CH2Cl2
  3. dry with materialThe CH2Cl2 extracts were dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated by rotary evaporator

出典と根拠

ORDレコード
ord-e4fd128355604a5c878d80fa0409e38f
出典データセット
uspto-grants-2012_06
特許番号
US08198311B2

関連ノート

読み込み中…