N-(2-fluoro-5-nitrophenyl)benzamide → N-(5-Amino-2-fluorophenyl)benzamide

HRID 2181557

反応式

HRID 2181557 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[NH:11][C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>[Pd].C1COCC1.CO>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([NH:11][C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:4]=1

参加物

4

反応物 1

HCID 675819N-(2-fluoro-5-nitrophenyl)benzamide

生成物 1

HCID 11148928N-(5-Amino-2-fluorophenyl)benzamide収率 91%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

A mixture of N-(2-fluoro-5-nitro-phenyl)-benzamide (4.86 g, 18.7 mmol) and 10% Pd/C, (486 mg) in a 1:1 mixture of THF-MeOH (80 ml) was hydrogenated at 23° C. After 25 h the reaction mixture was filtered through celite and concentrated to give N-(5-Amino-2-fluorophenyl)benzamide (3.92 g, 91%). MS (ESI+) [M+H]/z Calc'd 231, found 231.

後処理

  1. customwas hydrogenated at 23° C
  2. filtrationAfter 25 h the reaction mixture was filtered through celite and
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-f2be313b5e8043e2ac57d59255ed654d
出典データセット
uspto-grants-2005_05
特許番号
US06891044B2

関連ノート

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