Sodium Hydroxide → HCID 69795151、化合物

HRID 2181663ノート

反応式

HRID 2181663 の反応式
[NH2:1][C:2]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([O:15]C)=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)=[O:3].[OH-].[Na+]>CO.O>[NH2:1][C:2]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)=[O:3]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 22481693HCID 22481693、化合物

生成物 1

HCID 69795151HCID 69795151、化合物収率 93%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

Methyl 2-(aminocarbonyl)-1-benzofuran-6-carboxylate(164 mg, 0.75 mmol) is dissolved in MeOH (5 mL) and water (1 mL), treated drop-wise with 2N NaOH (450 μL, 0.9 mmol) and monitored by TLC. The volatiles are removed in vacuo, and the resulting tan solid is dissolved in water (5 mL) and acidified to pH 3 with concentrated HCl. The resulting solid is collected via filtration and dried in a vacuum oven with heat 50° C. to afford 142 mg (93%) of 2-(aminocarbonyl)-1-benzofuran-6-carboxylic acid as an orange solid. HRMS (EI) calcd for C10H7NO4: 205.0375, found 205.0378 (M)+.

後処理

  1. customThe volatiles are removed in vacuo
  2. dissolutionthe resulting tan solid is dissolved in water (5 mL)
  3. filtrationThe resulting solid is collected via filtration
  4. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-7aade1f6d7e34b47b9d9c483c4a4994f
出典データセット
uspto-grants-2005_05
特許番号
US06894042B2

反応ノート

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