Sodium Hydroxide → HCID 69794736、化合物

HRID 2181667ノート

反応式

HRID 2181667 の反応式
[C:1]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([O:15]C)=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[CH3:2].[OH-].[Na+]>CO.O>[C:1]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[CH3:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 22481734HCID 22481734、化合物

生成物 1

HCID 69794736HCID 69794736、化合物収率 93,124.703%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

Methyl 2-acetyl-1-benzofuran-6-carboxylate (155 mg, 0.71 mmol) is dissolved in MeOH (3 ml) and H2O (0.5 ml). 2N NaOH (0.39 ml, 0.78 mmol) is added drop-wise, and the reaction is stirred overnight. The volatiles are removed in vacuo, and the residue is dissolved in H2O (3 ml). Concentrated HCl is used to adjust the pH to 3, and the resulting precipitate is isolated via filtration and dried overnight to afford 135 g (93%) of 2-acetyl-1-benzofuran-6-carboxylic acid as a yellow solid. MS for C11H8O4, (ESI−) m/z: 202.7 (M−H)−.

後処理

  1. customThe volatiles are removed in vacuo
  2. dissolutionthe residue is dissolved in H2O (3 ml)
  3. customthe resulting precipitate is isolated via filtration
  4. customdried overnight

出典と根拠

ORDレコード
ord-88965b41741748a798df5bed403c52cc
出典データセット
uspto-grants-2005_05
特許番号
US06894042B2

反応ノート

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