Sodium Hydroxide → HCID 69795068、化合物

HRID 2181668ノート

反応式

HRID 2181668 の反応式
[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C:5]1[O:6][C:7]2[CH:13]=[C:12]([C:14]([O:16]C)=[O:15])[CH:11]=[CH:10][C:8]=2[CH:9]=1)[CH3:2].[OH-].[Na+]>CO.O>[CH2:19]([O:18][CH:4]([O:3][CH2:1][CH3:2])[C:5]1[O:6][C:7]2[CH:13]=[C:12]([C:14]([OH:16])=[O:15])[CH:11]=[CH:10][C:8]=2[CH:9]=1)[CH3:20]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 22481729HCID 22481729、化合物

生成物 1

HCID 69795068HCID 69795068、化合物収率 103.4%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

Methyl 2-(diethoxymethyl)-1-benzofuran-6-carboxylate (417 mg, 1.5 mmol) is dissolved in MeOH (8 ml) and H2O (2 ml). 2N NaOH (0.9 ml, 1.8 mmol) is added drop-wise, and the reaction is stirred for 4 days. The volatiles are removed in vacuo and the residue is dissolved in H2O (2 ml). Concentrated HCl is used to adjust the pH to 3, and the resulting precipitate is isolated via filtration and dried overnight to afford 410 mg (>100%, water present) of 2-(diethoxymethyl)-1-benzofuran-6-carboxylic acid as a brown solid. 1H NMR (400 MHz, CDCl3): δ 1.29, 3.72, 6.9, 7.66, 8.04, 8.29 ppm.

後処理

  1. customThe volatiles are removed in vacuo
  2. dissolutionthe residue is dissolved in H2O (2 ml)
  3. customthe resulting precipitate is isolated via filtration
  4. customdried overnight

出典と根拠

ORDレコード
ord-dc04a162a7ca4bdaac9b5d1b589b17c0
出典データセット
uspto-grants-2005_05
特許番号
US06894042B2

反応ノート

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