Sodium Hydroxide → HCID 69361512、化合物
反応式
[CH:1]([C:4]1[C:8]2[CH:9]=[C:10]([C:13]([O:15]C)=[O:14])[CH:11]=[CH:12][C:7]=2[O:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>CO.O>[CH:1]([C:4]1[C:8]2[CH:9]=[C:10]([C:13]([OH:15])=[O:14])[CH:11]=[CH:12][C:7]=2[O:6][CH:5]=1)([CH3:3])[CH3:2]参加物
5
実験手順
Methyl 3-isopropyl-1-benzofuran-5-carboxylate (1.20 g, 5.51 mmol) is dissolved in MeOH (20 ml) and water (4 ml), treated drop-wise with 2N NaOH (3.3 ml, 6.6 mmol) and stirred at RT for 2 days, then at 40° C. for 4 h. The volatiles are removed in vacuo, the residue is dissolved in water (10 ml) and the pH is adjusted to 3 with concentrated HCl. The resulting precipitate is isolated via filtration and dried overnight to afford 1.08 g (97%) of 3-isopropyl-1-benzofuran-5-carboxylic acid as a white solid. MS (ESI−) for C12H12O3 m/z: 203.0 (M−H)−.
後処理
- waitat 40° C. for 4 h
- customThe volatiles are removed in vacuo
- dissolutionthe residue is dissolved in water (10 ml)
- customThe resulting precipitate is isolated via filtration
- customdried overnight
出典と根拠
- ORDレコード
- ord-872d0176cf8b4d5a9b4aa67f1eec1f3a
- 出典データセット
- uspto-grants-2005_05
- 特許番号
- US06894042B2
反応ノート
読み込み中…