Ammonium Acetate → 1-(2',5'-Difluoro-1,1'-biphenyl-2-yl)ethylamine

HRID 2181900ノート

反応式

HRID 2181900 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15](=O)[CH3:16].C([O-])(=O)C.[NH4+].C([BH3-])#[N:24].[Na+]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH:15]([NH2:24])[CH3:16]

参加物

5

反応物 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224823961-(2',5'-Difluoro-1,1'-biphenyl-2-yl)ethanone

生成物 1

HCID 224822831-(2',5'-Difluoro-1,1'-biphenyl-2-yl)ethylamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The title compound was prepared from 1-(2′,5′-difluoro-1,1′-biphenyl-2-yl)ethanone (2.0 g, 8.6 mmol), anhydrous methanol (100 mL), ammonium acetate (13.3 g, 172 mmol), and sodium cyanoborohydride (1.08 g, 17.2 mmol) according to the procedure and in the same manner as described in Example 105, step b;

出典と根拠

ORDレコード
ord-9465f3c683de4a22b3818456430bdbc4
出典データセット
uspto-grants-2005_05
特許番号
US06894061B2

反応ノート

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