HCID 10104631、化合物 → Ammonia
反応式
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1>[Pd].C(O)C>[NH3:3].[N:3]1[CH:2]=[CH:7][CH:6]=[C:5]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[N:4]=1参加物
5
実験手順
A mixture of 1-(3-Chloro-6-pyridazinyl)-homopiperazine (5.56 g, 26.1 mmol), palladium on carbon (2.1 g, 10%) and ethanol (150 ml) was stirred under hydrogen overnight. The crude product was filtered through celite and evaporated. Chromatography on silica gel with dichloromethane, methanol and conc. ammonia (89:10:1) gave the title compound as free base. Yield 2.78 g, 60%, 185.0-186.9° C.
後処理
- filtrationThe crude product was filtered through celite
- customevaporated
出典と根拠
- ORDレコード
- ord-96e313cec7484ddd8e4d3919920d7067
- 出典データセット
- uspto-grants-2005_05
- 特許番号
- US06897219B2
反応ノート
読み込み中…