Hydrogen Bromide → Benzaldehyde, 2,3-dihydroxy-4-nitro-

HRID 218271ノート

反応式

HRID 218271 の反応式
C([O:4][C:5]1[C:12]([O:13]C)=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])(=O)C.Br>C(O)(=O)C>[OH:4][C:5]1[C:12]([OH:13])=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=[CH:9][C:6]=1[CH:7]=[O:8]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 21783433HCID 21783433、化合物

生成物 1

HCID 10442360Benzaldehyde, 2,3-dihydroxy-4-nitro-収率 91%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
150 °C

実験手順

43 (2.5 g, 10.5 mmol) was added to a solution of acetic acid (62.5 mL) and hydrobromic acid 48% (70 mL) and the reaction mixture was heated at 150° C. for 4 h. The reaction mixture was then cooled to rt and evaporated to dryness. The residue was diluted in hot CH2Cl2 (40 mL) and filtered. The filtrate was evaporated to dryness to give 44 (1.74 g, 91%) which was used as such in the next step:

後処理

  1. temperatureThe reaction mixture was then cooled to rt
  2. customevaporated to dryness
  3. additionThe residue was diluted in hot CH2Cl2 (40 mL)
  4. filtrationfiltered
  5. customThe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-ff0c615cad7d4dd096e5f930998f45a0
出典データセット
uspto-grants-2012_06
特許番号
US08198302B2

反応ノート

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